Company presentations & whitepapers
Mitomic Test Protocol Instruction Films
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MDNA Blood Collection
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MDNA Plasma Separation
Product marketing literature: EU only
Product marketing literature: Non-EU & rest of world
Publications: Prostate Cancer
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3.4 kb deletion clinical validation study published in the World Journal of Urology
World Journal of Urology March 2018, Volume 36, Issue 3, pp 341–348
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Use of the Prostate Core Mitomic Test in Repeated Biopsy Decision-Making: Real-World Assessment of Clinical Utility in a Multi-Center Patient Population
American Health and Drug Benefits, Dec 2016, 9(9): 497-501
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Mitochondria, prostate cancer, and biopsy sampling error
Discovery Medicine Apr 2013, 15(83):213-220
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3.4kb mitochondrial genome deletion serves as a surrogate predictive biomrker for prostate cancer in histopathologically benign biopsy cores
Canadian Urological Association Journal, 2010 Oct, 4(5):E118-122
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Accurate prediction of repeat prostate biopsy outcomes by a mitochondrial DNA deletion assay
Prostate Cancer and Prostatic Diseases 2010 Jan 19
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Prostate cancer: detection and monitoring using mitochondrial mutations as a biomarker
Methods of Cancer Diagnosis, Therapy and Prognosis. General Methods and Overviews, Lung Carcinoma and Prostate Carcinoma (Vol. 2) Hayat, M.A. (Ed). Springer. USA (2008). Chapter 32, pg. 439-462
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Mitochondrial genome deletion aids in the identification of both false and true negative prostate needle core biopsies
American Journal of Clinical Pathology 2008, 129(1), 57-66
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Somatic mitochondrial DNA mutations in prostate cancer and normal appearing adjacent glands in comparison to age-matched prostate samples without malignant histology
Journal of Molecular Diagnostics 2006, 8(3),1-8
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Altered metabolism and mitochondrial genome in prostate cancer
Journal of Clinical Pathology 2006, 59(1), 10-16
Publications: Endometriosis
Publications: Skin Cancer / Sun Damage
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Ultraviolet radiation exposure accelerates the accumulation of the aging-dependent T414G mitochondrial DNA mutation in human skin
Aging Cell 2007, 6(4), 557-564
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Real-time PCR analysis of a 3895 bp mitochondrial DNA deletion in non-melanoma skin cancer and its use as a quantitative marker for sunlight exposure in human skin
British Journal of Cancer 2006, 94, 1887-1893
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The incidence of both tandem duplications and the common deletion in mitochondrial DNA from three distinct categories of sun-exposed human skin and in prolonged culture of fibroblasts
Journal of Investigative Dermatology 2006, 126, 408-415
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The role of mitochondria in aging and carcinogenesis
Clinical and Experimental Dermatology 2006, 31(4), 548-52
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Towards a 'free radical theory of graying': Melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage
FASEB Journal 2006, 20(9), 1567-9
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The anti-psoriatic drug anthralin accumulates in keratinocyte mitochondria, dissipates mitochondrial membrane potential, and induces apoptosis through a pathway dependent on respiratory competent mitochondria
FASEB Journal 2005, 19(8), 1012-4
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Using mitochondrial DNA as a biosensor of early cancer development
British Journal of Cancer 2005, 93(3), 271-272
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Implications of using the ND1 gene as a control region for real-time PCR analysis of mitochondrial DNA deletions in human skin
Journal of Investigative Dermatology 2004, 122, 1518-1522
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The use of a 3895bp mitochondrial DNA deletion as a marker for sunlight exposure in human skin
Journal of Investigative Dermatology 2004, 123, 1020-1024
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Current pitfalls in the measurement of the 4977 bp mitochondrial DNA common deletion in human skin
Journal of Investigative Dermatology 2003, 120, 981-982
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Mitochondrial DNA damage in non-melanoma skin cancer
British Journal of Cancer 2003, 88, 90-95
Publications: Mitomic Technology
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A single mitochondrial DNA deletion accurately detects significant prostate cancer in men in the PSA ‘grey zone’
Mitomic Prostate Test clinical validation study published in the World Journal of Urology
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Mitochondrial and cancer: past, present, and future
BioMed Research Internation, 2013 (2013)
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Paired ductal carcinoma in situ and invasive breast cancer lesions in the D-Loop of the mitochondrial genome indicate a cancerization field effect
BioMed Research International, 2013 (2013)
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Mitochondrial and nuclear genomics and the emergence of personalized medicine
Human Genomics, July 5, 2012
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Facile Whole mtGenome Resequencing From Nipple Aspirate Fluid Using MitoChip v2.0
BMC Cancer 2008, 8:95
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Mitochondrial Genome Analysis in Biofluids For Early Cancer Detection and Monitoring
Expert Opinion on Medical Diagnostics 2008, 2(3), 263-275
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The mitochondrial genome: a biosensor for early cancer detection?
Expert Opinion on Medical Diagnostics 2007, 1(2), 1-13
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Clinical implications and utility of field cancerization
Cancer Cell International 2007, 7, 2
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Targeting homeostatic mechanisms of ER stress to increase susceptibility of cancer cells to apoptosis: The role of stress proteins ERdj5 and ERp57
British Journal of Cancer 2007, 96(7), 1062-1071
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Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence
PLoS Biology 2007, 5(5), 110
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Analysis of potential cancer biomarkers in mitochondrial DNA
Current Opinion in Molecular Therapeutics 2006, 8(6), 500-506
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Mitochondrial DNA as a potential tool for early cancer detection
Human Genomics 2006, 2(4), 252-257
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Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis
Journal of Cell Science, 2006, 119, 4315-4321
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The pseudomitochondrial genome influences mistakes in heteroplasmy interpretation
BMC Genomics 2006, 7, 185
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A maternal line study investigating the 4977-bp mitochondrial DNA deletion
Experimental Gerontology, 2003, 38, 567-571
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